This comparison evaluates the performance of Destruction Warlocks and Unholy Death Knights, highlighting their strengths and weaknesses. Using SimulationCraft, each spec was tested under various conditions to analyze their capabilities in level 80 end-game PvE gameplay. Updated for patch 11.0.5 of the The War Within expansion.
Performance ComparisonPatch 11.0.5
Unholy Death Knight+3.37% DPS
When simulating for maximum theoretical single-target DPS, Unholy Death Knights averaged 3.37% more DPS than Destruction Warlocks (+53K DPS).
Unholy Death Knight+26.42% DPS
When simulating for light AoE DPS potential, with small waves of adds, Unholy Death Knights averaged 26.42% more DPS than Destruction Warlocks (+611K DPS).
Destruction Warlock+2.07% DPS
When upgrading the gear for both specs by +44 ilvl, Destruction Warlock DPS improved the most, +2.07% more than Unholy Death Knight. In total, Destruction Warlocks DPS increased by 66.98% and Unholy Death Knights by 64.91%.
This category evaluates the burst DPS potential of each spec by simulating a short encounter with full raid buffs and bloodlust.
This category evaluates the solo DPS potential of each spec by simulating a typical solo delve encounter with no raid buffs.
This category evaluates the pure AoE DPS potential of each spec by simulating both specs to fight intense groups of adds, with nearly 16 adds at any given moment.
This category evaluates the performance of each spec when introducing occasional movement and stuns during boss encounters.
This category evaluates the latency tolerance of each spec by simulating both specs with moderate-to-high latency. This can indicate which spec performs better when facing high latency, whether due to far server/realm location or limited access to quality internet.
This category evaluates the skill level required to play each spec by simulating both specs with greatly reduced player skill. This can indicate which spec is more forgiving of mistakes or has a simpler rotation.
The comparisons above highlight some of the key differences between Destruction Warlock and Unholy Death Knight in the current meta, which can hopefully help you determine which spec to play or group up with.
Destruction Warlockvs Unholy Death Knight
Unholy Death Knight+3.37% DPS 
Destruction Warlock+2.07% DPS