This page is maintained to show how Assassination Rogues and Destruction Warlocks compare in PvE end-game at level 80 — and was last updated for patch 11.1.7 of the The War Within expansion.
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Comparing DPS (Assassination Rogue vs. Destruction Warlock)
Anytime the game updates, we run simulations using BiS profiles and SimulationCraft to analyze the current meta of all specs in WoW. Below shows which spec had the highest DPS for each category. To view more information in a category, click the Details button.
Performance ComparisonPatch 11.1.7
Destruction Warlock+3.05% DPS
When simulating for maximum theoretical single-target DPS, Destruction Warlocks averaged 3.05% more DPS than Assassination Rogues (+86K DPS).
Destruction Warlock+7.92% DPS
When simulating for light AoE DPS potential, with small waves of adds, Destruction Warlocks averaged 7.92% more DPS than Assassination Rogues (+265K DPS).
Assassination Rogue+1.82% DPS
When upgrading the gear for both specs by +46 ilvl, Assassination Rogue DPS improved the most, +1.82% more than Destruction Warlock. In total, Assassination Rogues DPS increased by 64.63% and Destruction Warlocks by 62.81%.
Destruction Warlock+67.45% DPS
When simulating for max single-target DPS with the new Single-Button Assistant, Destruction Warlocks averaged 67.45% more DPS than Assassination Rogues (+1M DPS).
This category evaluates the burst DPS potential of each spec by simulating a short encounter with full raid buffs and bloodlust.
This category evaluates the solo DPS potential of each spec by simulating a typical solo delve encounter with no raid buffs.
This category evaluates the pure AoE DPS potential of each spec by simulating both specs to fight intense groups of adds, with nearly 16 adds at any given moment.
This category evaluates the performance of each spec when introducing occasional movement and stuns during boss encounters.
This category evaluates the latency tolerance of each spec by simulating both specs with moderate-to-high latency. This can indicate which spec performs better when facing high latency, whether due to far server/realm location or limited access to quality internet.
This category evaluates the skill level required to play each spec by simulating both specs with greatly reduced player skill. This can indicate which spec is more forgiving of mistakes or has a simpler rotation.
The comparisons above highlight some of the key differences between Assassination Rogue and Destruction Warlock in the current meta, which can hopefully help you determine which spec to play or group up with.
Assassination Roguevs Destruction Warlock
Destruction Warlock+3.05% DPS 
Assassination Rogue+1.82% DPS